Table of Contents

• 1 A Brief History of Epigenetics 1
  Gary Felsenfeld
• 2 The Next Generation: Young Scientists Forging Exciting New Discoveries in Epigenetic Research 11
• 3 Overview and Concepts 47
  C. David Allis, Marie-Laure Caparros, Thomas Jenuwein, Monika Lachner, and Danny Reinberg
• 4 Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition 117
  Ronen Marmorstein and Ming-Ming Zhou
• 5 Erasers of Histone Acetylation: The Histone Deacetylase Enzymes 143
  Edward Seto and Minoru Yoshida
• 6 Structural and Functional Coordination of DNA and Histone Methylation 169
  Xiaodong Cheng
• 7 A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks 193
  Dinshaw J. Patel
• 8 Epigenetics in Saccharomyces cerevisiae 241
  Michael Grunstein and Susan M. Gasser
• 9 Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe 269
  Robin C. Allshire and Karl Ekwall
• 10 Neurospora crassa, a Model System for Epigenetics Research 295
  Rodolfo Aramayo and Eric U. Selker
• 11 Epigenetics of Ciliates 313
  Douglas L. Chalker, Eric Meyer, and Kazufumi Mochizuki
• 12 Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila 337
  Sarah C.R. Elgin and Gunter Reuter
• 13 Epigenetic Regulation in Plants 363
  Craig S. Pikaard and Ortrun Mittelsten Scheid
• 14 The Use of Mouse Models to Study Epigenetics 395
  Marnie Blewitt and Emma Whitelaw
• 15 DNA Methylation in Mammals 423
  En Li and Yi Zhang
• 16 RNAi and Heterochromatin Assembly 445
  Robert Martienssen and Danesh Moazed
• 17 Transcriptional Silencing by Polycomb-Group Proteins 463
  Ueli Grossniklaus and Renato Paro
• 18 Transcriptional Regulation by Trithorax-Group Proteins 489
  Robert E. Kingston and John W. Tamkun
• 19 Long-Range Chromatin Interactions 507
  Job Dekker and Tom Misteli
• 20 Histone Variants and Epigenetics 529
  Steven Henikoff and M. Mitchell Smith
• 21 Nucleosome Remodeling and Epigenetics 555
  Peter B. Becker and Jerry L. Workman
• 22 Maintenance of Epigenetic Information 575
  Genevive Almouzni and Howard Cedar
• 23 Regulation of the X Chromosomes in Caenorhabditis elegans 599
  Susan Strome, William G. Kelly, Sevinc Ercan, and Jason D. Lieb
• 24 Dosage Compensation in Drosophila 621
  John C. Lucchesi and Mitzi I. Kuroda
• 25 Dosage Compensation in Mammals 641
  Neil Brockdorff and Bryan M. Turner
• 26 Genomic Imprinting in Mammals 667
  Denise P. Barlow and Marisa S. Bartolomei
• 27 Germline and Pluripotent Stem Cells 687
  Wolf Reik and M. Azim Surani
• 28 Induced Pluripotency and Epigenetic Reprogramming 711
  Konrad Hochedlinger and Rudolf Jaenisch
• 29 Epigenetic Control of Immunity 737
  Meinrad Busslinger and Alexander Tarakhovsky
• 30 Metabolic Signaling to Chromatin 763
  Shelley L. Berger and Paolo Sassone-Corsi
• 31 Epigenetic Regulation in Plant Responses to the Environment 787
  David C. Baulcombe and Caroline Dean
• 32 Histone and DNA Modifications as Regulators of Neuronal Development and Function 807
  Stavros Lomvardas and Tom Maniatis
• 33 Epigenetics and Human Disease 831
  Huda Y. Zoghbi and Arthur L. Beaudet
• 34 Epigenetic Determinants of Cancer 859
  Stephen B. Baylin and Peter A. Jones
• 35 Histone Modifications and Cancer 895
  James E. Audia and Robert M. Campbell
• 36 The Necessity of Chromatin: A View in Perspective 927
  Vincenzo Pirrotta